Scientists discover a missing linkage between poor diet and higher cancer risk

A National University of Singapore (NUS) research team uncovered insights linking cancer risk and poor diet, alongside conditions like diabetes. Their study, conducted by scientists from CSI Singapore at NUS and N2CR, with collaborators from A*STAR, focused on individuals with a high genetic risk of breast or ovarian cancer due to BRCA2 mutations. They found these individuals were more sensitive to methylglyoxal, a byproduct of glucose breakdown, which can induce early DNA abnormalities indicating cancer development. Additionally, their work challenged the traditional 'two-hit' paradigm, suggesting methylglyoxal temporarily deactivates cancer-suppressing genes, potentially increasing cancer risk with repeated poor dietary episodes or uncontrolled diabetes. This research offers promise for enhancing cancer prevention strategies, particularly in promoting healthy ageing.