Paleolithic diets are not without risks

High-protein diets, or "Paleolithic diets," are popular for weight management and stabilizing diabetes but come with risks. Research from the University of Geneva (UNIGE) using mouse models shows that while these diets can be effective, they significantly increase ammonium production, which can overwhelm the liver and lead to neurological disorders or coma.

Type 2 diabetes is on the rise due to sedentary lifestyles and rich diets. Although treatments manage diabetes, they do not cure it, and weight loss is crucial. Paleolithic diets, rich in animal or plant proteins, can help stabilize diabetes and aid in weight control.

Ammonium, a byproduct of protein breakdown, is normally processed by the liver enzyme glutamate dehydrogenase (GDH). In mice with functional GDH, the liver manages excess ammonium. However, mice lacking GDH face toxic ammonium buildup, leading to severe health issues. Those with GDH enzyme deficiencies should be cautious with high-protein diets and consider GDH activity testing.