Reduction in folate intake associated with healthier aging in animal models

A study published in *Life Science Alliance* by Texas A&M AgriLife Research challenges the belief that high folate intake universally benefits health. Researchers found that reduced folate intake improved metabolic flexibility in aging animal models, suggesting potential benefits for healthier aging. Folate, a B vitamin found in leafy greens and added to refined grains, is known for preventing birth defects, but its long-term health effects are less clear.

The study observed that lowering folate led to decreased cell growth processes but enhanced metabolic flexibility, potentially supporting healthier aging. This suggests that optimal folate intake may vary with age, with lower intake possibly benefiting older adults.

The research highlights the need for personalized dietary recommendations and precision nutrition. While folate fortification has addressed deficiencies in some groups, it may not be beneficial for all, particularly older adults. Further research is needed to understand these effects and develop targeted interventions for healthy aging.