Rutgers Maps Brain’s Tug-of-War Over Hunger

Rutgers scientists have uncovered two competing brain circuits that control hunger and satiety—revealing why current weight-loss drugs like Ozempic have limits. One circuit, rich in GLP-1 receptors, suppresses appetite when activated; another triggers intense cravings. During fasting, the hunger circuit becomes more sensitive, while the satiety circuit weakens—reversing after eating.

These findings, from two studies in Nature, explain how energy states rewire the brain quickly, and why targeting just one pathway often leads to side effects or drug resistance. Using tools like optogenetics and chemogenetics, researchers could precisely control these neural signals. Future therapies may fine-tune these circuits, reducing side effects and improving results. Instead of constantly dampening appetite, smarter drugs could help the brain naturally rebalance cravings and fullness—offering a new frontier in obesity treatment.

22-06-2025