Microplastics Linked to Alzheimer’s-Like Changes in Genetically Susceptible Mice

A new study from the University of Rhode Island College of Pharmacy shows that micro- and nanoplastics can accumulate in the brain and accelerate Alzheimer’s-like changes, particularly in individuals with genetic risk factors. Published in Environmental Research Communications, the research examined mice carrying the APOE4 gene, which increases Alzheimer’s risk, and compared them to mice with the APOE3 variant.

Over three weeks, APOE4 and APOE3 mice were exposed to polystyrene microplastics through drinking water. The particles infiltrated organs, including the brain. Behavioral tests revealed sex-specific impacts: APOE4 males exposed to microplastics showed reduced fear responses, while females demonstrated impaired memory during object recognition tests—patterns that mirror human Alzheimer’s symptoms.

The findings suggest environmental toxins like microplastics may interact with genetic risks to influence disease progression. Researchers stress the need for expanded studies on human health impacts and stronger regulation of microplastic exposure.

22-09-2025