PFAS Chemicals Found to Disrupt Liver Function, Trigger Fat Buildup and Cancer-Linked Changes

A new study published in Environment International reveals that toxic “forever chemicals” (PFAS) fundamentally disrupt human liver function by causing fat accumulation and activating cancer-related pathways. Researchers exposed miniature human liver models (“spheroids”) from ten donors to four common PFAS compounds — PFOA, PFHxS, PFOS, and PFNA — for one week. PFOA increased fat production, while PFHxS made cells retain fat, both leading to fatty liver changes. PFOS and PFNA triggered cancer-associated pathways, with PFNA showing the strongest effects, including heightened inflammation, oxidative stress, and DNA repair responses.

The effects were sex-specific, with PFOA impacting female liver cells more strongly and PFOS affecting male cells. Researchers suggest FDA-approved drugs that regulate fat metabolism could be tested for PFAS-induced damage but stressed the need for personal precautions, such as filtered water and avoiding nonstick cookware, to reduce exposure before regulatory action catches up.

17-09-2025