Artificial Sweeteners Linked to Faster Cognitive Decline in Middle Age

A study published in Neurology® suggests that high consumption of artificial sweeteners may be associated with faster memory and thinking decline in adults under 60, particularly those with diabetes. Researchers tracked 12,772 adults in Brazil, with an average age of 52, over eight years. Participants reported their dietary intake, including seven sweeteners commonly found in ultra-processed foods and drinks.

Those consuming the highest amounts—averaging 191 mg/day—showed a 62% faster decline in cognitive performance, equivalent to about 1.6 years of aging, compared to those consuming the least (20 mg/day). The decline was most evident in verbal fluency and memory and was stronger among people with diabetes. No associations were found in adults over 60.

Aspartame, saccharin, acesulfame-K, erythritol, sorbitol, and xylitol were linked to poorer cognition, while tagatose showed no effect. Researchers emphasized that the findings indicate an association, not causation, and further studies are needed.

06-09-2025