Both Regular and Diet Soft Drinks Linked to Higher Fatty Liver Risk

A large-scale study presented at UEG Week 2025 reveals that both sugar-sweetened (SSBs) and low- or no-sugar-sweetened beverages (LNSSBs) increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers analyzed data from 123,788 UK Biobank participants with no initial liver issues, tracking their beverage habits over a decade. Individuals consuming over 250 grams daily of either drink faced markedly higher risks—60% for LNSSBs and 50% for SSBs. LNSSB intake was also associated with greater liver-related mortality. The study suggests SSBs contribute to liver fat buildup through glucose spikes and weight gain, while LNSSBs may alter gut microbiota and insulin response. Replacing these beverages with water reduced MASLD risk by up to 15%. Researchers emphasize limiting both regular and “diet” soft drinks, noting water as the healthiest choice for liver and overall metabolic health.

19-10-2025