Gut-Brain Link, Not Gluten, May Drive “Gluten Sensitivity”

A new review published in The Lancet reveals that most cases of so-called gluten sensitivity may stem from gut-brain interactions and fermentable carbohydrates rather than gluten itself. Affecting up to 10% of people worldwide, non-celiac gluten sensitivity (NCGS) often causes bloating, pain, and fatigue.

Researchers from Australia, The Netherlands, Italy, and the UK analyzed past studies and found that only a small fraction of participants showed real gluten-specific reactions, while most symptoms were linked to FODMAPs, other wheat components, or psychological factors such as expectation.

The findings suggest that NCGS is part of a broader gut-brain interaction spectrum, similar to irritable bowel syndrome. Scientists urge clinicians to focus on personalized care, combining dietary adjustments with psychological support. The study also calls for more accurate diagnosis and a shift in public messaging—moving away from the belief that gluten itself is inherently harmful.

02-11-2025