Hidden Helper Protein Found to Play Key Role in Appetite Control

Scientists have identified a previously overlooked protein that plays a critical role in regulating appetite and energy balance. New research shows that an appetite-controlling protein cannot function effectively on its own and instead relies on a helper protein to keep hunger signals working properly. When this support system fails, energy balance in the body may be disrupted, increasing obesity risk.

In a study published December 16 in Science Signaling, researchers led by the University of Birmingham examined how a helper protein called MRAP2 supports MC3R, a receptor involved in deciding whether the body stores or burns energy. Using cell models, the team found that MRAP2 strengthens MC3R signaling, helping maintain healthy appetite regulation.

When MRAP2 carried genetic mutations linked to obesity, this support weakened and appetite signaling declined. The findings suggest that disruptions in MRAP2 may contribute to genetic obesity and highlight the protein as a potential future target for therapies aimed at improving appetite control and energy balance.

23-12-2025