Leucine Identified as a Key Nutrient That Boosts Cellular Energy

Scientists have discovered that leucine, an essential amino acid found in foods such as meat, dairy, and legumes, plays a direct role in enhancing mitochondrial energy production. A team led by Professor Thorsten Hoppe at the University of Cologne has shown that leucine prevents the breakdown of crucial proteins on the outer mitochondrial membrane, helping mitochondria operate more efficiently. Their study, published in Nature Cell Biology, demonstrates that leucine strengthens the organelle’s ability to generate energy by stabilizing these transport proteins.

The researchers found that leucine also interacts with SEL1L, a quality-control protein responsible for removing damaged cellular components. By reducing SEL1L’s activity, leucine helps preserve mitochondrial proteins, boosting respiration. Experiments in C. elegans and human lung cancer cells revealed that disruptions in leucine metabolism can impair mitochondrial function and influence disease processes. The findings highlight leucine’s broader importance for energy regulation and potential therapeutic applications.

18-11-2025