Low Choline and Early Metabolic Stress May Trigger Hidden Brain Changes in Young Adults

New research indicates that obesity-related biological changes affecting the brain may begin far earlier than expected. Scientists from Arizona State University and collaborating institutions found that young adults with obesity already show signs of inflammation, liver strain and early neuronal injury—patterns typically associated with older adults at risk for cognitive decline. A key observation was that many participants had unusually low blood choline levels, a nutrient essential for liver function, inflammation control and memory-related neurotransmission.

The study identified elevated neurofilament light chain (NfL), a marker of neuronal damage, which strongly correlated with reduced choline in participants with obesity. These metabolic and neurological shifts mirror those seen in adults with mild cognitive impairment or Alzheimer’s disease.

Because many people, especially young adults, fall short of recommended choline intake, the findings highlight the importance of choline-rich foods in supporting long-term metabolic and brain health.

02-12-2025