Genes and Vitamin B1 Influence Bowel Habits

A new study in Gut suggests that genetics and vitamin B1 (thiamine) play key roles in regulating bowel movement frequency. Researchers analyzed data from 268,606 people of European and East Asian ancestry, identifying 21 genomic regions linked to stool frequency, including 10 previously unknown. Many genes confirmed established pathways, such as bile-acid regulation and nerve signaling controlling intestinal muscle contractions.

Surprisingly, two genes involved in thiamine transport and activation, SLC35F3 and XPR1, showed strong effects. Analysis of 98,449 UK Biobank participants revealed that higher dietary thiamine intake increased bowel movement frequency, with effects dependent on individual genetic variation.

The findings may explain part of the biology behind IBS, constipation, and other gut-motility disorders. Researchers hope the results will guide future lab studies and clinical trials exploring how thiamine supplementation could support digestive health in genetically susceptible individuals.

26-01-2026