Gut Bacteria Compound May Reduce Childhood Fatty Liver Risk Before Birth

New research from the University of Oklahoma suggests that a small molecule produced by healthy gut bacteria could help protect children from fatty liver disease, even before they are born. Children exposed to high-fat, high-sugar diets during pregnancy and breastfeeding are known to face a higher risk of metabolic dysfunction–associated steatotic liver disease (MASLD). In a mouse study published in eBioMedicine, researchers found that this risk was significantly reduced when mothers received indole, a compound created by beneficial gut bacteria during the breakdown of the amino acid tryptophan.

Offspring born to indole-supplemented mothers showed healthier liver function, lower body weight, improved blood sugar control, and smaller fat cells, despite later exposure to unhealthy diets. The protective effects were linked to changes in the gut microbiome and activation of beneficial metabolic pathways.

While the findings are limited to animal models, they highlight the potential of improving maternal gut health as an early strategy to prevent childhood fatty liver disease.

08-02-2026