High Antioxidant Intake May Have Unexpected Risks, Study Finds

Antioxidants are widely viewed as beneficial for preventing disease and supporting overall health. However, new research from Texas A&M University College of Veterinary Medicine and Biomedical Sciences suggests that excessive intake could have unintended consequences, particularly for reproductive health.

Published in Frontiers in Cell and Developmental Biology, the study examined the effects of two common antioxidants—N-acetyl-L-cysteine (NAC) and selenium—in mice. Researchers found that males given high doses over several weeks produced offspring with noticeable changes in skull and facial development, despite showing no visible health issues themselves.

The findings indicate that excessive antioxidant levels may alter sperm DNA, potentially affecting how offspring develop. Female offspring appeared more significantly impacted, showing features linked to developmental irregularities.

Researchers emphasize that while antioxidants play an important role in reducing oxidative stress, overconsumption may disrupt biological balance. The study highlights the importance of moderation, especially for individuals taking high-dose supplements without medical guidance.

27-03-2026