Rare Risk of Severe Pancreatitis with GLP-1 Weight Loss Injections

Users of GLP-1 medications like Wegovy, Ozempic, and Mounjaro should be aware of a rare but serious risk of acute pancreatitis, a severe inflammation of the pancreas. The MHRA advises patients to watch for persistent, severe stomach or back pain, possibly with nausea and vomiting, and to seek medical attention immediately if these occur.

While hundreds of reports exist, no cases have been definitively linked to these drugs. About 1.6 million adults in the UK have used GLP-1s in the past year.

Dr Alison Cave, MHRA Chief Safety Officer, emphasized that GLP-1 medicines are generally safe and effective, but awareness of potential side effects is critical. Most cases of pancreatitis resolve within a week, though severe cases can cause complications.

Patients should only take GLP-1 drugs prescribed by a healthcare professional and discuss benefits and risks before starting or switching treatments.

03-02-2026